Optogenetics Relieves Depression in a Mouse Trial
* By David Dobbs Email Author
* November 30, 2010
* 5:00 pm
* Categories: Neuron Culture, Science Blogs
* Wired magazine
Forget about Area 51. The action is at Area 25.
"...A team of researchers has used light to make a mouse’s brain run better and relieve the mouse’s mousy version of depression....This optogenetic work suggests a less intrusive, even more exacting way to test, define, and tweak...[brain] circuits.
"The researchers, led by Stanford University’s Karl Deisseroth and UT Southwestern psychiatrist Eric Nestler, used optogenetics — a technique that makes specific neurons sensitive to light and then lets you use light to activate or silence them — to increase activity in a key part of a mouse’s prefrontal cortex.
"As the researchers put it,
"...[O]ptogenetic stimulation of mPFC exerted potent antidepressant-like effects, without affecting general locomotor activity, anxiety-like behaviors, or social memory. These results indicate that the activity of the mPFC is a key determinant of depression-like behavior, as well as antidepressant responses."
This is a line of research that has been yielding excellent results for some time. Read more HERE.